Biovorin Injection contains Calcium Leucovorin, a folinic acid used to reduce the toxic effects of certain chemotherapy drugs like methotrexate. It is also used in combination with 5-fluorouracil (5-FU) to enhance anticancer effects. Calcium Leucovorin acts as a chemoprotectant and is vital in rescue therapy during high-dose methotrexate treatments, helping protect healthy cells without reducing the effectiveness of chemotherapy.

• Reduces toxicity from high-dose methotrexate

• Enhances effectiveness of 5-fluorouracil in cancer treatment

• Acts as a folate supplement in certain anemias

• Supports recovery of healthy cells during chemotherapy

Biovorin Injection is administered by a healthcare professional, typically by intravenous (IV) or intramuscular (IM) injection. The dose and frequency depend on the indication, methotrexate levels, and patient condition.

• Dose varies widely based on therapeutic use (e.g., methotrexate rescue, 5-FU combination)

• In methotrexate rescue: usually starts 24 hours after methotrexate administration

• Administered every 6 hours or as prescribed, with careful monitoring of methotrexate plasma levels

• Only to be used under the supervision of a qualified healthcare provider

• Not for use in patients with known hypersensitivity to folinic acid or its components

• Caution in patients with seizure disorders or vitamin B12 deficiency

• Monitor kidney and liver function during treatment

• May interact with certain antibiotics and antiepileptics—inform your doctor of all ongoing medications

• Not a suitable substitute for folic acid in megaloblastic anemia caused by vitamin B12 deficiency

• Common side effects may include:

• Injection site reactions (pain, redness)

• Nausea or vomiting

• Fatigue

• Allergic reactions (rash, swelling, difficulty breathing)

• Seizures in patients with underlying neurological conditions

• Seek immediate medical attention in case of severe reactions.

  Rare but serious side effects:

• Store at 2°C to 8°C (refrigerated)

• Do not freeze

• Protect from light and keep in the original container

• Keep out of reach of children

Q1. What is Biovorin Injection used for?
It is used to reduce toxic side effects of methotrexate and to enhance the efficacy of 5-fluorouracil in cancer therapy.

Q2. Is Biovorin the same as folic acid?
No. Biovorin is folinic acid (a form of active folate) and is used differently from folic acid, especially in cancer treatment.

Q3. Can Biovorin be self-administered?
No. It must be administered by a trained healthcare professional.

Q4. How long is Biovorin given after methotrexate?
It is usually given 24 hours after methotrexate and continued based on methotrexate levels and clinical condition.