Celkeran (Chlorambucil) is an alkylating agent used in the treatment of chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma, and other cancers. It works by interfering with the DNA in cancer cells, preventing their ability to divide and grow. This oral medication is usually prescribed when other therapies are not effective or suitable for the patient. Chlorambucil is considered a relatively mild chemotherapy drug, effective for managing cancers and autoimmune diseases like rheumatoid arthritis and nephrotic syndrome.

• Targeted cancer treatment: Effective for chronic lymphocytic leukemia, Hodgkin's lymphoma, and other cancers

• Oral administration: Convenient oral tablet form compared to intravenous chemotherapy

• Milder side effects: Relatively well-tolerated when compared to other chemotherapy treatments

• Improves prognosis: Used to control the spread of cancer and improve quality of life in cancer patients

• Used for autoimmune conditions: Effective in treating conditions like nephrotic syndrome and rheumatoid arthritis

• Dosage: The typical starting dose is 2 mg per day, which can be adjusted based on the patient's response and condition.

• Administration: Swallow the tablet whole with a full glass of water. Do not crush or chew the tablet.

• Consistency: It is important to take your dose consistently as prescribed by your healthcare provider.

• Missed Dose: If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Do not double the dose.

• Course of Treatment: Treatment is often cyclical, with periods of administration followed by breaks, depending on the disease being treated.

• Active Ingredient: Chlorambucil (2 mg per tablet)

• Recommended Dose: Start with 2 mg per day or as prescribed by your healthcare provider

• Administration: Oral (with water)

• Combination Therapy: Chlorambucil is often combined with other medications depending on the condition being treated

• Blood counts: Regular monitoring of blood counts is required due to the potential for bone marrow suppression

• Liver Function: Chlorambucil can affect liver function. Periodic liver function tests are recommended

• Pregnancy: Celkeran is contraindicated in pregnancy and should not be used during pregnancy unless absolutely necessary due to potential risks to the fetus.

• Breastfeeding: Should not be used during breastfeeding as it can pass into breast milk

• Drug Interactions: Inform your doctor of all medications you are taking, especially other chemotherapy agents, immunosuppressive drugs, and blood thinners

• Common: Nausea, vomiting, fatigue, hair loss

• Serious: Bone marrow suppression (low blood counts), liver damage, lung toxicity, and increased risk of infection

• Other: Rash, fever, or swelling of lymph nodes

• Contact your healthcare provider if you experience any unusual symptoms such as bleeding, bruising, or persistent fever.

• Store at room temperature between 20°C and 25°C

• Keep in a tightly closed container to protect from light and moisture

• Do not store in the bathroom or areas with high humidity

• Keep out of the reach of children

• Dispose of unused medication in accordance with local disposal guidelines

Q1. What is Celkeran used for?
A: Celkeran (Chlorambucil) is primarily used for treating chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma, and other cancers. It is also used for certain autoimmune diseases like nephrotic syndrome.

Q2. How should I take Celkeran?
A: Take one 2 mg tablet per day with a full glass of water, unless directed otherwise by your doctor. Do not crush or chew the tablet.

Q3. What are the side effects of Celkeran?
A: Some common side effects include nausea, vomiting, and fatigue. Serious side effects include bone marrow suppression, liver damage, and lung toxicity. Notify your doctor if you notice unusual symptoms.

Q4. Can Celkeran be taken during pregnancy?
A: No, Celkeran is contraindicated in pregnancy due to potential harm to the unborn baby. It should only be used if absolutely necessary.

Q5. How should I store Celkeran?
A: Store Celkeran at room temperature, in a dry place away from light and moisture. Keep it in its original container and out of reach of children.