Glucophage is a brand name for metformin hydrochloride, an oral medication used to manage type 2 diabetes mellitus. It works by reducing glucose production in the liver, decreasing intestinal glucose absorption, and enhancing insulin sensitivity in peripheral tissues. This combination helps lower blood sugar levels and is often used in conjunction with diet and exercise.

• Reduces blood sugar levels in individuals with type 2 diabetes.

• Enhances insulin sensitivity, aiding in better glucose utilization.

• Does not cause weight gain and may assist in modest weight loss.

• Does not cause low blood sugar (hypoglycemia) when used alone.

• May have cardiovascular benefits, including potential reductions in heart-related events.

Take one 500 mg tablet orally, typically with meals to reduce the risk of gastrointestinal side effects. Swallow the tablet whole with a glass of water. Your healthcare provider will determine the appropriate dosage and may adjust it based on your blood sugar levels and tolerance.

• Starting Dose: Usually, 500 mg once or twice daily.

• Maintenance Dose: May be increased gradually to 1500–2550 mg per day, divided into 2 or 3 doses.

• Maximum Dose: Do not exceed 2550 mg per day.

• Note: Dosage adjustments are based on individual response and tolerability.

• Contraindicated in individuals with severe renal impairment, acute or chronic metabolic acidosis, including diabetic ketoacidosis, and hypersensitivity to metformin.

• Use with caution in patients with liver disease, heart failure, or those who consume excessive alcohol.

• Regular monitoring of kidney function is recommended during treatment.

• Temporarily discontinue metformin before certain procedures involving contrast agents or during periods of dehydration.

Common side effects may include:

• Gastrointestinal issues: nausea, vomiting, diarrhea, abdominal discomfort.

• Metallic taste.

• Loss of appetite.

Serious but rare side effects include:

• Lactic acidosis: a potentially life-threatening condition.

• Vitamin B12 deficiency with long-term use.

If you experience unusual fatigue, muscle pain, or breathing difficulties, seek immediate medical attention.

Store at room temperature, between 15°C and 30°C (59°F and 86°F), in a dry place away from direct sunlight. Keep out of reach of children.

Q1: Can I take Glucophage with other diabetes medications?
Yes, Glucophage is often used in combination with other oral antidiabetic agents or insulin to achieve better blood sugar control. Your healthcare provider will determine the appropriate combination.

Q2: Is Glucophage safe during pregnancy?
The safety of Glucophage during pregnancy has not been established. Consult your healthcare provider for alternatives if you are planning to become pregnant or are pregnant.

Q3: Can Glucophage be used in children?
Glucophage is approved for use in children aged 10 years and older for the treatment of type 2 diabetes. Dosage adjustments are based on the child's weight and response to treatment.

Q4: Does Glucophage cause low blood sugar?
When used alone, Glucophage does not cause hypoglycemia. However, when combined with other antidiabetic medications, the risk of low blood sugar may increase.

Q5: How long does it take for Glucophage to work?
You may start to see improvements in blood sugar levels within the first week of treatment, but it may take up to 2 to 3 months to see the full benefits.