Glypride 4 mg Tablets contain Glimepiride, a second-generation sulfonylurea used to treat type 2 diabetes mellitus. Glimepiride lowers blood glucose by stimulating pancreatic β-cells to release insulin and improving insulin sensitivity in peripheral tissues. It is prescribed when diet and exercise alone do not provide adequate glycemic control.

• Effectively reduces fasting and post-meal blood glucose

• Promotes endogenous insulin secretion in a glucose-dependent manner

• Can be combined with other oral agents or insulin

• Once-daily dosing enhances adherence

• Cost-effective and widely available

• Take one 4 mg tablet once daily, with breakfast or the first main meal

• Swallow whole with water; do not crush or chew

• Maintain consistent meal timing relative to dosing

• Continue prescribed diet and exercise regimen

• Standard dose: 4 mg once daily

• May be started at 1 mg and titrated up based on blood glucose response

• Maximum recommended daily dose: 8 mg

• Dose adjustments required in hepatic or renal impairment

• If a dose is missed, take it as soon as remembered—unless it’s close to the next scheduled dose; do not double up

• Contraindicated in type 1 diabetes, diabetic ketoacidosis, and sulfonylurea hypersensitivity

• Caution in patients with severe hepatic or renal dysfunction

• Monitor for signs of hypoglycemia, especially in elderly or debilitated patients

• Avoid alcohol, which may potentiate hypoglycemia or cause a disulfiram-like reaction

• Common:

• Hypoglycemia (sweating, shakiness, confusion)

• Headache

• Less common/serious:

• Hematologic changes (leukopenia, thrombocytopenia)

• Allergic skin reactions (rash, pruritus)

• Hepatic dysfunction (rare)

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• Dizziness

• Weight gain

• Store at room temperature (15 °C – 30 °C)

• Protect from moisture and light

• Keep in original blister until use

• Keep out of reach of children

Q1. What if I experience a hypoglycemic episode?
Consume 15 – 20 g of fast-acting carbohydrate (e.g., glucose tablets), recheck blood glucose in 15 minutes, and repeat if necessary. Inform your physician if episodes recur.

Q2. Can Glypride be used during pregnancy?
No. Sulfonylureas are generally avoided in pregnancy; insulin is the preferred agent.

Q3. How should I adjust my dose if I have kidney disease?
Your physician will determine appropriate dosing—often starting at lower doses and monitoring renal function closely.

Q4. Can I drink alcohol while on Glypride?
Alcohol can increase hypoglycemia risk or cause disulfiram-like reactions; it’s best to avoid or limit intake.