Istavel D Tablet is a dual-acting oral antidiabetic medication that combines Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, and Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor. This combination is used for the effective management of type 2 diabetes mellitus in adults. Dapagliflozin reduces glucose reabsorption in the kidneys, promoting glucose excretion through urine, while Sitagliptin enhances incretin hormones to stimulate insulin release and suppress glucagon. Together, they help improve glycemic control without causing significant hypoglycemia or weight gain.

• Dual mechanism of action for comprehensive blood sugar control

• Reduces both fasting and postprandial blood glucose levels

• Promotes weight loss and helps reduce blood pressure

• Low risk of hypoglycemia when used without insulin or sulfonylureas

• Once-daily dosing for improved patient convenience

• Take the tablet once daily, with or without food

• Swallow whole with water; do not crush or chew

• Take at the same time each day for best results

• Always follow the dosage prescribed by your healthcare provider

• Dosage is individualized based on the patient’s medical condition, response to treatment, and kidney function

• Commonly initiated in patients who require dual therapy for enhanced glycemic control

• Not recommended in patients with severe renal impairment or on dialysis

• Regular monitoring of kidney function, blood sugar, and electrolytes is advised

• Maintain adequate hydration to avoid dehydration or urinary tract infections

• Not suitable for use in type 1 diabetes or for treatment of diabetic ketoacidosis

• Inform your doctor if you have a history of genital infections, kidney problems, or low blood pressure

• Common side effects:

• Frequent urination

• Urinary tract or genital infections

• Serious but rare side effects:

• Hypoglycemia (especially when combined with insulin or sulfonylureas)

• Dehydration

• Ketoacidosis (requires immediate medical attention)

• Pancreatitis

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• Headache

• Nasal congestion or sore throat

• Store at room temperature (15°C to 30°C)

• Keep away from direct sunlight and moisture

• Do not use if the tablet appears damaged or expired

• Keep out of reach of children

Q1. Who can benefit from Istavel D?
Patients with type 2 diabetes who are inadequately controlled on monotherapy or require dual therapy for better glucose control.

Q2. Can Istavel D help with weight loss?
Yes, Dapagliflozin may contribute to modest weight loss due to increased glucose excretion.

Q3. Does this tablet cause low blood sugar?
When taken alone, the risk is low. However, combining it with insulin or sulfonylureas may increase the chance of hypoglycemia.

Q4. Is Istavel D safe for long-term use?
Yes, it is safe for long-term use under the supervision of a healthcare provider with regular monitoring.