Janumet 50 mg/1000 mg Tablets combine two active ingredients: Sitagliptin (50 mg) and Metformin Hydrochloride (1000 mg). This fixed-dose combination is used to manage type 2 diabetes mellitus in adults when diet, exercise, and monotherapy with either agent alone do not provide adequate glycemic control. Sitagliptin enhances the body’s incretin system to promote insulin release, while Metformin reduces hepatic glucose production and improves insulin sensitivity.

• Dual mechanism for effective blood glucose control

• Improves both fasting and postprandial glucose levels

• Convenient combination in a single tablet

• Lowers the risk of hyperglycemia without causing significant weight gain

• Can reduce the need for additional medications

• Take the tablet orally twice daily, usually with meals to reduce gastrointestinal side effects

• Swallow whole with water; do not crush or chew

• Adhere strictly to the dosage and schedule prescribed by your doctor

• Standard adult dose: 50 mg Sitagliptin + 1000 mg Metformin, twice daily

• Dosage may be adjusted based on individual response, kidney function, and tolerability

• Not recommended for patients with significantly impaired renal function

• Not for use in type 1 diabetes or diabetic ketoacidosis

• Monitor kidney function regularly, especially in elderly patients

• Inform your doctor of any history of pancreatitis, liver issues, or alcohol abuse

• Risk of lactic acidosis increases with dehydration, excessive alcohol, or kidney impairment

• Common side effects:

• Nausea

• Diarrhea

• Serious but rare side effects:

• Lactic acidosis (medical emergency)

• Pancreatitis

• Vitamin B12 deficiency with long-term use

• Hypoglycemia (when used with insulin or sulfonylureas)

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• Headache

• Upper respiratory tract infections

• Store at room temperature (15°C to 30°C)

• Keep away from moisture and heat

• Do not use expired medication

• Keep out of reach of children

Q1. What is the advantage of using Janumet over taking Sitagliptin and Metformin separately?
Janumet combines both medicines in one tablet, simplifying the regimen and improving adherence.

Q2. Can Janumet cause low blood sugar?
The risk is low when used alone but increases if taken with insulin or sulfonylureas.

Q3. What should I do if I miss a dose?
Take it as soon as you remember unless it’s almost time for the next dose. Do not double the dose.

Q4. Is Janumet safe for long-term use?
Yes, under medical supervision, Janumet is suitable for long-term management of type 2 diabetes.