Janumet 50 mg/500 mg Tablets contain a combination of Sitagliptin (50 mg) and Metformin Hydrochloride (500 mg), two oral antihyperglycemic agents used to manage type 2 diabetes mellitus. Sitagliptin is a DPP-4 inhibitor that increases incretin levels to stimulate insulin secretion and reduce glucagon levels. Metformin is a biguanide that lowers glucose production in the liver and improves insulin sensitivity. This formulation is typically used when blood sugar is not adequately controlled with Metformin alone.

• Provides synergistic control of blood sugar levels

• Improves both fasting and postprandial glucose readings

• Helps reduce HbA1c effectively

• May delay disease progression and complications

• Weight-neutral with low risk of hypoglycemia

• Take one tablet twice daily, preferably with meals to minimize gastrointestinal side effects

• Swallow the tablet whole with water

• Use consistently at the same times each day

• Usual starting dose: 50 mg Sitagliptin / 500 mg Metformin twice daily

• Dose may be increased gradually depending on glycemic response and tolerability

• Not suitable for patients with significantly impaired kidney function

• Not intended for use in type 1 diabetes or diabetic ketoacidosis

• Kidney function must be monitored regularly

• Use with caution in elderly patients and those at risk of dehydration

• Discuss use during pregnancy or breastfeeding with a healthcare provider

• Common side effects:

• Nausea

• Diarrhea

• Rare but serious side effects:

• Lactic acidosis (especially in those with kidney or liver dysfunction)

• Pancreatitis

• Vitamin B12 deficiency with long-term use

• Hypoglycemia when used with insulin or sulfonylureas

•  

• Headache

• Mild abdominal discomfort

• Store at room temperature (15°C to 30°C)

• Protect from moisture, heat, and light

• Keep in original packaging

• Keep out of reach of children

Q1. Why is Janumet 50/500 commonly prescribed?
It’s often the starting dose for patients needing combination therapy to better control blood sugar levels.

Q2. Can Janumet cause low blood sugar?
Not typically when used alone, but risk increases when combined with insulin or other hypoglycemics.

Q3. What if I miss a dose?
Take it as soon as you remember, unless it's near your next scheduled dose. Never double the dose.

Q4. Is it necessary to take Janumet with food?
Yes, taking it with meals helps reduce gastrointestinal discomfort caused by Metformin.