Kisqali (Ribociclib) is a prescription medication used to treat certain types of breast cancer, specifically hormone receptor-positive, HER2-negative breast cancer in combination with aromatase inhibitors. It works as a CDK4/6 inhibitor that helps prevent cancer cell division by blocking proteins that are essential for cancer cell growth. This medication is typically used for postmenopausal women or men in combination with other cancer treatments. Kisqalican slow the progression of cancer, improving the patient's quality of life.

• Effective in HR-positive Breast Cancer: Works in combination with aromatase inhibitors to treat hormone receptor-positive, HER2-negative breast cancer.

• CDK4/6 Inhibition: Blocks CDK4 and CDK6, proteins that are crucial for cancer cell division, which helps to stop or slow cancer cell growth.

• Improved Treatment Outcomes: Studies have shown that Kisqali, when combined with letrozole or other hormone therapies, improves progression-free survival in breast cancer patients.

• Well-Tolerated: Many patients tolerate Kisqali well, with side effects generally being manageable.

• Administration: Kisqali is taken orally in the form of a tablet.

• Dosage: The typical recommended dose is one 200 mg tablet taken once daily for 21 consecutive days, followed by a 7-day break. This is part of a 28-day treatment cycle.

• Combination Therapy: Kisqali is used in combination with letrozole, tamoxifen, or other hormone therapies.

• Swallow Whole: Do not crush, break, or chew the tablet; swallow it whole with or without food.

• Follow Doctor’s Instructions: Always follow your doctor’s recommendations for dosage and scheduling.

• Strength: 200 mg per tablet

• Form: Oral tablets

• Typical Dosage: 200 mg taken once daily for 21 days out of every 28-day cycle. This regimen can be adjusted based on individual treatment plans.

• Discontinuation: Treatment may be paused or stopped if side effects occur or if cancer progression is observed.

• Liver Function Monitoring: Regular liver function tests are required before and during treatment with Kisqali, as it may affect liver enzymes.

• QT Interval Prolongation: Kisqali can cause QT prolongation, which can lead to serious heart problems. Patients with existing heart conditions should be closely monitored.

• Pregnancy Category: Kisqali should not be used during pregnancy, as it can cause harm to the fetus. Women should use effective contraception during treatment.

• Neutropenia: Low white blood cell count (neutropenia) is a possible side effect. Regular blood tests will be needed.

• Drug Interactions: Kisqali may interact with other medications. Ensure your healthcare provider is aware of all the medications you are taking.

• Common Side Effects:

  • Fatigue

  • Nausea

  • Diarrhea

  • Headache

  • Loss of appetite

  • Hair thinning or hair loss

• Serious Side Effects:

  • Liver damage (elevated liver enzymes)

  • QT prolongation (heart rhythm problems)

  • Low white blood cell count (neutropenia), increasing the risk of infection

  • Severe allergic reactions such as rash, swelling, or difficulty breathing

  • Blood clots or deep vein thrombosis (DVT)

• Temperature: Store Kisqali at room temperature (15°C to 30°C).

• Keep out of Reach of Children: Ensure the medication is stored in a safe place, away from children.

• Avoid Moisture: Keep the tablets in their original packaging to protect them from moisture.

Q1. How is Kisqali administered?
A: Kisqali is taken orally, once daily, with or without food. It is typically taken for 21 days followed by a 7-day break, as part of a 28-day cycle.

Q2. Can Kisqali be used during pregnancy?
A: No, Kisqali should not be used during pregnancy due to the risk of harm to the fetus. Women should use effective contraception during treatment.

Q3. What are the side effects of Kisqali?
A: Common side effects include fatigue, nausea, diarrhea, headache, and hair thinning. Serious side effects include liver damage, QT prolongation, and neutropenia.

Q4. How often should I have blood tests while taking Kisqali?
A: Regular blood tests are required to monitor for potential side effects, particularly liver function and blood cell counts.

Q5. Can Kisqali be taken with other medications?
A: Kisqali may interact with other medications. Always inform your healthcare provider of any other medicines you are taking, including over-the-counter drugs.