Lupride Depot 11.25 mg is a long-acting formulation of Leuprolide Acetate, a synthetic gonadotropin-releasing hormone (GnRH) agonist. It is administered as a single intramuscular injection every 12 weeks and is primarily used to treat hormone-sensitive conditions such as prostate cancer, endometriosis, uterine fibroids, and central precocious puberty (CPP). By suppressing sex hormone levels, it helps control disease progression and alleviate symptoms.

• Long-acting 3-month treatment option for hormone-dependent conditions

• Effectively lowers testosterone (in men) and estrogen (in women)

• Reduces symptoms associated with prostate cancer, endometriosis, and CPP

• Convenient quarterly dosing improves patient compliance

• Helps in shrinking fibroid tumors and managing menstrual pain

• Administration: Intramuscular injection by a healthcare provider

• Schedule: Every 12 weeks (once every 3 months)

• Preparation: Reconstitute with the supplied sterile diluent before injection

• Monitoring: Regular hormonal evaluation and clinical monitoring required during therapy

• Active Ingredient: Leuprolide Acetate 11.25 mg

• Standard Dosing:

  • Prostate cancer: 11.25 mg IM every 12 weeks

  • Endometriosis / Fibroids: 11.25 mg IM every 12 weeks for up to 6 months

  • CPP in children: Based on weight and clinical response

• Adjustments: Based on therapeutic response and tolerance

• Contraindicated in pregnancy and breastfeeding

• Use cautiously in patients with osteoporosis, seizure disorders, or heart disease

• Initial “flare-up” of hormones may temporarily worsen symptoms

• Bone density monitoring is recommended during long-term use

• Not recommended for use beyond recommended treatment duration without evaluation

• Common Side Effects:

• Hot flushes

• Headache

• Fatigue

• Decreased libido

• Serious Side Effects:

• Bone thinning (osteoporosis)

• Depression or mood changes

• Blood sugar fluctuations

• Cardiovascular risks (rare)

• Seizures (rare)

• Seek immediate medical attention if experiencing severe allergic reactions, chest pain, or unusual mood swings.

• Injection site pain

• Store below 25°C

• Keep in the original packaging to protect from light

• Reconstituted solution should be used immediately

• Keep out of reach of children

Q1. What is Lupride Depot 11.25 mg used for?
A: It is used for treating prostate cancer, endometriosis, uterine fibroids, and central precocious puberty.

Q2. How often is it administered?
A: Once every 12 weeks via intramuscular injection.

Q3. Can Lupride Depot cause menopause-like symptoms?
A: Yes, symptoms such as hot flashes and mood swings may occur due to reduced estrogen levels.

Q4. Is long-term use safe?
A: Extended use may lead to bone loss, so doctors often recommend limiting therapy duration or combining it with add-back therapy.

Q5. Can it be used in children?
A: Yes, under medical supervision, it is used to treat central precocious puberty.