Lupride Depot 3.75 mg is a long-acting injectable formulation containing Leuprolide Acetate, a GnRH (Gonadotropin-Releasing Hormone) agonist. It is used for the treatment of hormone-sensitive conditions such as prostate cancer, endometriosis, uterine fibroids, and precocious puberty. By regulating hormone levels, it helps suppress the production of estrogen and testosterone, slowing the progression of hormone-dependent conditions.

• Reduces testosterone levels in advanced prostate cancer

• Controls estrogen production in endometriosis and uterine fibroids

• Manages central precocious puberty (CPP) in children

• Offers monthly sustained release with depot formulation

• Helps delay disease progression and relieve associated symptoms

• Administration: Intramuscular injection by a healthcare professional

• Frequency: Once every 4 weeks

• Preparation: Reconstitute with provided diluent before use

• Monitoring: Regular blood tests and hormone evaluations recommended

• Active Ingredient: Leuprolide Acetate 3.75 mg

• Standard Dosage:

  • Prostate cancer: 3.75 mg IM every 4 weeks

  • Endometriosis/Uterine Fibroids: 3.75 mg IM every 4 weeks (up to 6 months)

  • CPP in children: Dosage based on weight and response

• Adjustment: Based on response and tolerability

• Not for use in pregnant or breastfeeding women

• May cause an initial hormone flare-up before suppression

• Use with caution in patients with osteoporosis or cardiovascular risks

• Hormone levels must be monitored periodically

• May affect blood sugar or increase risk of seizures in certain populations

• Common Side Effects:

• Hot flashes

• Headaches

• Mood swings

• Decreased libido

• Serious Side Effects:

• Bone thinning (osteoporosis) with long-term use

• Increased risk of diabetes or cardiovascular problems

• Hormone withdrawal effects

• Seizures (rare)

• Seek medical help if symptoms like chest pain, difficulty breathing, or severe depression occur.

• Injection site reactions

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Use immediately after reconstitution

• Keep out of reach of children

Q1. What is Lupride Depot 3.75 mg used for?
A: It is used to treat hormone-responsive conditions like prostate cancer, endometriosis, and precocious puberty.

Q2. How long does Lupride take to work?
A: Initial response may take 1–2 weeks, with full hormone suppression typically within a month.

Q3. Can women take Lupride Depot?
A: Yes, it's commonly prescribed for endometriosis and fibroids, but it is not for use during pregnancy.

Q4. Are there long-term risks?
A: Prolonged use may cause bone density loss; your doctor may suggest calcium/vitamin D supplements or limit treatment duration.

Q5. Is hormone flare-up dangerous?
A: It’s usually temporary but may worsen symptoms initially. Doctors may prescribe additional medications to manage this phase.