Nublexa 40 mg contains Regorafenib, a multikinase inhibitor used in the treatment of advanced cancers, including metastatic colorectal cancer (mCRC), gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (HCC). It works by blocking multiple enzymes (kinases) that promote cancer cell growth and blood supply to tumors, thereby inhibiting tumor progression.

• Effective in managing metastatic colorectal cancer after standard therapies

• Treats advanced gastrointestinal stromal tumors resistant to imatinib and sunitinib

• Helps control advanced liver cancer (HCC) in patients previously treated with sorafenib

• Targets multiple pathways involved in tumor growth and angiogenesis

• Oral formulation for convenient administration

• Take orally once daily with a low-fat meal

• Swallow the tablet whole with water—do not crush or chew

• Take at the same time each day

• Treatment cycles usually follow a 3 weeks on / 1 week off regimen, or as directed by the oncologist

• Active Ingredient: Regorafenib 40 mg

• Typical Adult Dose: 160 mg once daily for the first 21 days of each 28-day cycle

• Dose adjustments may be necessary based on tolerance and liver function

• Do not exceed the prescribed dosage

• Not recommended during pregnancy or breastfeeding

• Monitor liver function tests before and during treatment

• Use caution in patients with hypertension, heart disease, or bleeding disorders

• Regular monitoring of blood pressure, CBC, and liver enzymes is advised

• Avoid grapefruit and its juice, which may increase drug levels

• Common Side Effects:

• Fatigue

• Diarrhea

• Loss of appetite

• Hand-foot skin reaction (HFSR)

• Serious Side Effects:

• Liver toxicity

• Severe bleeding

• Heart problems

• Gastrointestinal perforation

• Seek immediate medical attention if you experience chest pain, yellowing of eyes/skin, or black/tarry stools.

• High blood pressure

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep out of reach of children

• Use the tablets within 7 weeks of opening the bottle

Q1. What is Nublexa 40 mg used for?
A: Nublexa is used to treat advanced cancers, including colorectal cancer, GIST, and liver cancer.

Q2. Can I take Nublexa with food?
A: Yes, take it with a low-fat meal to ensure proper absorption and minimize side effects.

Q3. How long does it take to show results?
A: It varies by patient and condition. Doctors typically assess response after one or more cycles.

Q4. What precautions should I take during treatment?
A: Regular blood tests, liver function monitoring, and blood pressure checks are necessary.

Q5. Can I stop taking it if I feel better?
A: No, always consult your oncologist before stopping. Premature discontinuation can reduce treatment efficacy.