Oxitan Injection contains Oxaliplatin, a chemotherapy drug that belongs to the class of platinum-based compounds. It is widely used in the treatment of colorectal cancer, particularly for patients with metastatic colorectal cancer or those who have not responded to previous treatments. Oxaliplatin works by interfering with the cancer cell's ability to replicate its DNA, preventing the cells from dividing and causing their death. This treatment is typically administered as part of a combination chemotherapy regimen.

• Effective for colorectal cancer: Used to treat advanced and metastatic colorectal cancer

• Part of combination therapy: Typically administered in combination with other chemotherapy agents, such as 5-fluorouracil (5-FU) and leucovorin

• Improves survival: Proven to improve overall survival rates in patients with advanced colorectal cancer

• Well-tolerated in many patients: Many patients respond well to the drug, improving disease management

• Adjuvant treatment: Can be used as part of adjuvant chemotherapy following surgical resection of tumors

• Intravenous administration: Oxitan is administered through an IV infusion. It should only be given by a healthcare professional experienced in chemotherapy administration.

• Standard dosage: The typical dose is 85 mg/m² of body surface area (BSA), though this can vary depending on the specific regimen and patient condition.

• Infusion time is usually 2 to 6 hours, with regular monitoring during the infusion.

• Often administered every 2 weeks as part of a chemotherapy cycle.

• Active Ingredient: Oxaliplatin

• Concentration: Available in a 50 ml vial, with varying mg concentrations depending on the regimen. Confirm the dosage before administration.

• Dosage Schedule: Commonly, 85 mg/m² is administered every two weeks. However, the dosage may vary depending on specific patient conditions and treatment protocols.

• The dosage may be adjusted for renal impairment, and careful monitoring is required to prevent toxicity.

• Contraindications: Do not administer to patients with a known hypersensitivity to oxaliplatin or other platinum-containing compounds.

• Precautions: Use with caution in patients with renal or hepatic dysfunction.

• Pregnancy Category: Not recommended during pregnancy or breastfeeding due to potential harm to the fetus.

• Regular monitoring of liver function, kidney function, and complete blood count (CBC) is necessary.

• Avoid exposure to cold temperatures after administration, as it may cause severe neuropathy.

• Common Side Effects:

• Peripheral neuropathy (tingling or numbness in the hands or feet)

• Nausea and vomiting

• Serious Side Effects:

• Severe allergic reactions (difficulty breathing, swelling of face or throat)

• Respiratory problems (e.g., pulmonary fibrosis)

• Liver toxicity

• Neutropenia (low white blood cell count, increasing risk of infection)

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• Fatigue

• Diarrhea

• Anemia or low white blood cell count

• Store at 2°C to 8°C (refrigerated). Do not freeze the vial.

• Keep the vial in its original packaging to protect it from light.

• After dilution, the solution should be used within 24 hours if stored at room temperature or 48 hours when stored in the refrigerator.

• Keep out of reach of children and dispose of any unused medication according to local regulations.

Q1. What is Oxitan used for?
A: Oxitan is primarily used to treat metastatic colorectal cancer, either as a part of a combination therapy or as an adjuvant to surgery.

Q2. How is Oxitan administered?
A: Oxitan is given through an intravenous (IV) infusion, typically administered by a healthcare provider in an oncology clinic or hospital.

Q3. What should I do if I miss a dose?
A: If you miss a dose, contact your healthcare provider immediately to reschedule your treatment. Missing doses may affect the effectiveness of your chemotherapy regimen.

Q4. Are there any dietary restrictions while using Oxitan?
A: While there are no specific dietary restrictions, it is important to follow any instructions provided by your oncologist regarding hydration and anti-nausea medications.

Q5. How do I manage the side effects of Oxitan?
A: Side effects like nausea, vomiting, and fatigue can be managed with medications prescribed by your doctor. Cold-induced neuropathy can be minimized by avoiding cold exposure after treatment.