Oxitan Injection contains Oxaliplatin, a chemotherapy drug that belongs to the class of platinum-based compounds. It is widely used in the treatment of colorectal cancer, particularly for patients with metastatic colorectal cancer or those who have not responded to previous treatments. Oxaliplatin works by interfering with the cancer cell's ability to replicate its DNA, preventing the cells from dividing and causing their death. This treatment is typically administered as part of a combination chemotherapy regimen.

• Effective for colorectal cancer: Used to treat advanced and metastatic colorectal cancer

• Part of combination therapy: Typically administered in combination with other chemotherapy agents, such as 5-fluorouracil (5-FU) and leucovorin

• Improves survival: Proven to improve overall survival rates in patients with advanced colorectal cancer

• Well-tolerated in many patients: Many patients respond well to the drug, improving disease management

• Adjuvant treatment: Can be used as part of adjuvant chemotherapy following surgical resection of tumors

• Intravenous administration: Oxitan is administered through an IV infusion. It should only be given by a healthcare professional experienced in chemotherapy administration.

• Standard dosage: The typical dose is 85 mg/m² of body surface area (BSA), though this can vary depending on the specific regimen and patient condition.

• Infusion time is usually 2 to 6 hours, with regular monitoring during the infusion.

• Often administered every 2 weeks as part of a chemotherapy cycle.

• Active Ingredient: Oxaliplatin

• Concentration: Available in a 50 ml vial, with varying mg concentrations depending on the regimen. Confirm the dosage before administration.

• Dosage Schedule: Commonly, 85 mg/m² is administered every two weeks. However, the dosage may vary depending on specific patient conditions and treatment protocols.

• The dosage may be adjusted for renal impairment, and careful monitoring is required to prevent toxicity.

• Contraindications: Do not administer to patients with a known hypersensitivity to oxaliplatin or other platinum-containing compounds.

• Precautions: Use with caution in patients with renal or hepatic dysfunction.

• Pregnancy Category: Not recommended during pregnancy or breastfeeding due to potential harm to the fetus.

• Regular monitoring of liver function, kidney function, and complete blood count (CBC) is necessary.

• Avoid exposure to cold temperatures after administration, as it may cause severe neuropathy.

• Common Side Effects:

• Peripheral neuropathy (tingling or numbness in the hands or feet)

• Nausea and vomiting

• Serious Side Effects:

• Severe allergic reactions (difficulty breathing, swelling of face or throat)

• Respiratory problems (e.g., pulmonary fibrosis)

• Liver toxicity

• Neutropenia (low white blood cell count, increasing risk of infection)

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• Fatigue

• Diarrhea

• Anemia or low white blood cell count