Paxlovid 300 mg Tablets is an oral antiviral medication used in the treatment of mild to moderate COVID-19 in individuals who are at high risk of developing severe illness. It combines two active components: Nirmatrelvir (300 mg) and Ritonavir (100 mg). Nirmatrelvir inhibits the SARS-CoV-2 virus from replicating, while Ritonavir enhances its effectiveness by slowing its breakdown in the body.

Timely administration—within 5 days of symptom onset—is critical for Paxlovid to reduce the risk of hospitalization or death.

• Helps prevent progression to severe COVID-19

• Reduces symptoms and duration of illness

• Suitable for high-risk patients with underlying conditions

• Oral tablet form, convenient for at-home use

• Emergency Use Authorization granted in many countries

• Treatment of mild to moderate COVID-19 in adults and adolescents (12 years of age and older, weighing at least 40 kg)

• Recommended for patients at high risk of developing severe disease, including older adults or those with underlying health conditions (e.g., diabetes, obesity, cardiovascular disease)

• One dose consists of 2 tablets of Nirmatrelvir 150 mg (totaling 300 mg) and 1 tablet of Ritonavir 100 mg, taken together

• Administered twice daily for 5 days

• Tablets can be taken with or without food

• Do not miss doses and do not exceed the prescribed duration

• Consult a healthcare provider for dose adjustments if the patient has moderate renal or hepatic impairment

• Not recommended for patients with severe renal or liver impairment

• Must not be used with medications that are highly dependent on CYP3A for clearance and are associated with serious reactions when plasma concentrations increase

• Should be taken only under medical supervision

• Use during pregnancy or breastfeeding should be based on medical advice

Common side effects may include:

• Altered taste

• Diarrhea

• High blood pressure

• Muscle aches

Less common but serious side effects include:

• Liver enzyme elevations

• Allergic reactions

• Drug interactions causing adverse effects with other medications

Seek immediate medical attention if any signs of allergic reaction or liver issues occur, such as yellowing of the skin or eyes, or severe abdominal pain.

Avoid using Paxlovid with:

• Certain sedatives and anticonvulsants (e.g., carbamazepine, phenytoin)

• Some cholesterol-lowering drugs (e.g., simvastatin, lovastatin)

• Herbal supplements like St. John’s Wort

• Drugs that are potent CYP3A inducers or inhibitors

Always consult with a healthcare professional before combining Paxlovid with other medications.

• Store at room temperature (15–30°C)

• Keep in a dry place, away from direct light and moisture

• Keep out of reach of children

• Do not use after the expiration date on the packaging

Q1: What is Paxlovid 300 mg used for?
It is used to treat mild to moderate COVID-19 in people at high risk of progressing to severe illness.

Q2: How should I take Paxlovid?
Take 2 tablets of Nirmatrelvir 150 mg and 1 tablet of Ritonavir 100 mg, twice daily for 5 days. Follow your doctor's instructions.

Q3: Can I use Paxlovid if I am already hospitalized with COVID-19?
No, it is not authorized for use in patients who are already hospitalized for severe COVID-19.

Q4: What if I miss a dose?
Take it as soon as possible unless it's almost time for your next dose. Do not double up on doses.

Q5: Is Paxlovid safe during pregnancy?
The safety of Paxlovid during pregnancy is not fully established. It should be used only if clearly needed and prescribed by a doctor.