Pegstim Injection contains Pegfilgrastim, a long-acting form of filgrastim (G-CSF), used to reduce the risk of infectionin patients undergoing chemotherapy. It helps the body produce more white blood cells (neutrophils), which are essential in fighting infections, especially when the immune system is suppressed during cancer treatment.

• Prevents neutropenia (low neutrophil count) caused by chemotherapy

• Reduces the incidence of infection, such as febrile neutropenia

• Decreases the need for hospitalization and IV antibiotics

• Once-per-cycle dosing improves patient convenience

• Enhances the body's immune defense during chemotherapy

• Administered as a subcutaneous injection (under the skin)

• Given once per chemotherapy cycle, usually 24 hours after the end of chemotherapy

• Only a healthcare professional should administer this medication

• Do not shake the syringe or vial before use

• Dispose of used syringes safely in a sharps container

• Strength: 6 mg/0.6 ml (single prefilled syringe)

• Route: Subcutaneous injection

• Frequency: Once per chemotherapy cycle

• Timing: 24 hours post-chemotherapy (not within 14 days before the next chemo)

• Not for use in patients with a history of serious allergic reactions to Pegfilgrastim or filgrastim

• Use caution in patients with sickle cell disease or myeloid malignancies

• Can cause splenic rupture (report left upper abdominal pain)

• Regular blood count monitoring is advised

• Do not use in pregnancy or breastfeeding unless prescribed by a physician

• Avoid injecting into bruised, red, or irritated skin

Common Side Effects:

• Bone pain

• Muscle and joint pain

• Headache

• Fatigue

• Nausea

Serious Side Effects:

• Splenic rupture (rare but potentially life-threatening)

• Allergic reactions: rash, swelling, shortness of breath

• Adult respiratory distress syndrome (ARDS)

• Capillary leak syndrome

• Store in a refrigerator between 2°C and 8°C (36°F and 46°F)

• Do not freeze

• Keep in the original carton to protect from light

• Allow the injection to come to room temperature for 30 minutes before use

• Discard if left out for more than 48 hours

Q1. What is Pegstim used for?
A: It is used to prevent neutropenia (low white blood cells) caused by chemotherapy.

Q2. How is Pegstim different from filgrastim?
A: Pegstim is a long-acting form, requiring fewer injections (once per cycle vs daily for filgrastim).

Q3. Can I inject Pegstim at home?
A: It should be administered by a healthcare professional or under direct supervision.

Q4. Is it normal to feel bone pain after injection?
A: Yes, bone or muscle pain is a common side effect and usually mild to moderate.

Q5. Can Pegstim be reused?
A: No, it is a single-use prefilled syringe and must be discarded after use.