Proluton Depot 250 mg contains Hydroxyprogesterone Caproate, a synthetic form of progesterone used to reduce the risk of preterm labor in pregnant women with a history of spontaneous preterm birth. It supports pregnancy maintenance by helping to relax the uterine muscles and stabilize the uterine lining. The medication is administered via intramuscular injection for sustained release.

• Reduces the risk of recurrent preterm labor in high-risk pregnancies

• Supports uterine relaxation and maintenance of pregnancy

• Long-acting formulation allows for weekly dosing

• Helps improve neonatal outcomes by prolonging pregnancy duration

Proluton Depot 250 mg is given as an intramuscular injection by a healthcare provider, typically in the gluteal or thigh muscle. The injection is administered once weekly, beginning between 16 to 20 weeks of gestation and continuing until 36 weeks or delivery.

• Standard dose: 250 mg intramuscularly once per week

• Duration: From 16-20 weeks gestation until 36 weeks or delivery

• Follow your healthcare provider’s dosing schedule strictly

• Contraindicated in cases of unexplained vaginal bleeding, active thrombophlebitis, liver disease, or hormone-sensitive cancers

• Inform your doctor if you have blood clotting disorders, cardiovascular disease, or allergies to progesterone

• Use only under strict medical supervision during pregnancy

• Report any adverse effects to your healthcare provider immediately

Common side effects include:

• Pain, swelling, or redness at injection site

• Mild nausea

• Breast tenderness

• Headache

• Fatigue

Serious side effects (rare):

• Allergic reactions (rash, itching, swelling)

• Blood clots or symptoms of thrombosis

• Mood changes, depression

Seek urgent medical attention if you experience chest pain, shortness of breath, leg swelling, or severe allergic reactions.

Store the medication refrigerated at 2–8°C. Protect from light and do not freeze. Keep out of reach of children. Use before the expiration date on the label.

Q: What is the purpose of Proluton Depot 250 mg?
A: It is used to lower the risk of preterm birth in pregnant women with a history of spontaneous preterm labor.

Q: How is this medication administered?
A: It is given as a weekly intramuscular injection by a healthcare professional.

Q: When should treatment start and end?
A: Treatment typically starts between 16 and 20 weeks of pregnancy and continues until 36 weeks or delivery.

Q: What side effects should I expect?
A: Injection site discomfort, mild nausea, breast tenderness, headache, and fatigue are common.

Q: Can I self-administer Proluton Depot?
A: No, it must be administered by a healthcare provider to ensure safety and proper dosing.