Proluton Depot contains Hydroxyprogesterone Caproate, a long-acting synthetic progesterone used to prevent preterm labor in pregnant women with a history of spontaneous preterm birth. Administered via intramuscular injection, it helps maintain pregnancy by supporting the uterine lining and reducing uterine contractions.

• Helps prevent preterm labor in high-risk pregnancies

• Supports maintenance of pregnancy by mimicking natural progesterone effects

• Administered as a long-acting injection, requiring less frequent dosing

• Can improve pregnancy outcomes and reduce neonatal complications related to prematurity

Proluton Depot is administered as an intramuscular injection by a healthcare professional, typically in the buttock or thigh muscle. The usual schedule is once weekly, starting from the second trimester (around 16 to 20 weeks) until 36 weeks of gestation or delivery.

• Standard dose: 500 mg (1 mL) administered intramuscularly once a week

• Treatment duration: From 16-20 weeks gestation up to 36 weeks or delivery

• Always follow your healthcare provider’s specific instructions on dosage and schedule

• Not recommended for women with unexplained vaginal bleeding, active thrombophlebitis, liver disease, or hormone-sensitive cancers

• Inform your healthcare provider if you have a history of blood clots, cardiovascular disease, or allergic reactions to progesterone

• Use only under medical supervision during pregnancy

• Report any adverse reactions promptly to your healthcare provider

Common side effects include:

• Injection site pain or swelling

• Mild nausea

• Breast tenderness

• Headache

• Fatigue

Serious side effects (rare):

• Allergic reactions (rash, itching, swelling)

• Blood clots or signs of thrombosis

• Mood changes or depression

Seek immediate medical attention if you experience symptoms such as chest pain, difficulty breathing, leg swelling, or severe allergic reactions.

Store Proluton Depot in a refrigerator at 2–8°C. Protect from light and do not freeze. Keep out of reach of children. Use before the expiration date printed on the packaging.

Q: What is Proluton Depot used for?
A: It is used to prevent preterm labor in pregnant women who have a history of spontaneous preterm birth.

Q: How is Proluton Depot administered?
A: It is given as an intramuscular injection once weekly by a healthcare professional.

Q: When should treatment with Proluton Depot start and end?
A: Treatment usually begins between 16 to 20 weeks of pregnancy and continues until 36 weeks or delivery.

Q: Are there any common side effects?
A: Injection site pain, mild nausea, breast tenderness, headache, and fatigue are common.

Q: Can Proluton Depot be used without medical supervision?
A: No, it must be administered and monitored by a healthcare professional during pregnancy.